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Korean Journal of Otorhinolaryngology-Head and Neck Surgery > Volume 60(4); 2017 > Article
구강설을 침범한 전이성 간세포암종 1예

Abstract

Hepatocellular carcinoma (HCC) is a common neoplasm, and its metastasis to the head and neck area is rare. We herein describe a unique case of HCC metastasis to the dorsal tongue. A 54-year-old male who was already diagnosed with HCC visited our hospital complaining of dysphagia and a progressively enlarging dorsal tongue mass. We operated to excise on the mass using CO2 laser including mucosal margin and deep margin. The diagnosis of HCC metastasis was confirmed immunohistochemically. After 2 weeks of follow-up, the patient did not exhibit any evidence of complication and could eat orally without any problem. Further treatment to the other metastatic lesion was rejected, and the patient was followed up for more than six months. We introduce this first case of metastatic HCC in the dorsal tongue. With the extended life expectancy of HCC patients, the incidence of rare metastasis is expected to increase.

Introduction

Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies globally. HCC may indicate intrahepatic multiple occurrence and intrahepatic metastases. Extrahepatic metastasis of HCC takes place in about 30-50% of patients, and it is determined by HCC stages. The location of extrahepatic metastasis of HCC is mainly the lung [1]. Extrahepatic metastases to various unusual sites from HCC have been informed of several case reports [2-4]. Metastatic malignancy of tongue is very rare, only one case of oropharyngeal tongue base, and we could not find any previous paper about HCC in dorsal surface of oral tongue in English literature [5]. The author reports on a case of an extrahepatic metastasis from HCC in the oral tongue.

Case

The patient involved was a 54-year-old male with HCC, chronic hepatitis B and liver cirrhosis. He underwent surgery at 16 months ago, segmentectomy of the liver, and Transarterial chemoembolization was implemented 5 times due to intrahepatic carcinoma recurrence. After 1 year that, HCC was spreaded to lung and brain. He then underwent wedge resection of lung and Gamma Knife surgery of the brain. After 4 month, he came to our department complaining of dysphagia and a progressively enlarging odorful dorsal tongue mass for 4 months. On physical examination, a pinkish lobulated hard mass measuring 2×2 cm located on the dorsal of the tongue. No enlargement of the cervical lymph nodes was discovered (Fig. 1).
Computed tomography (CT) scans of the dorsum of tongue demonstrated a 1.8 cm well-defined, lobulated mass with good enhancement (Fig. 2A) and known intracranial metastatic mass at Lt. occipital lobe (Fig. 2B). A postoperative positron emission tomography-CT showed bone, muscle (right buttock), brain, and multiple peritoneal seeding metastases probably from HCC. A preoperative workup showed that a liver function evaluation (AST 25 U/L, ALT 39 U/L) with coagulation profile were normal. But it showed an elevated PIVKA II (591 mAU/mL). We placed a Denhart mouth gag, approached the lesion intraorally, and exposed it by pulling and anchoring the tongue with Vicryl 4-0. We totally excised the mass using a CO2 laser; we included a 1-cm-deep cancer-free mucosal margin and a deep margin. The defect was closed with Vicryl 3-0. The patient was discharged 1 day later without any complications. Microscopically, the tumor exhibited a trabecular growth pattern, featuring plates of various thickness separated by sinusoid vascular spaces (Fig. 3A). The diagnosis of HCC metastasis was confirmed immunohistochemically, in that the tumor cells were positive for glypican-3 and hepatocyte-specific antigen (Fig. 3B). The minimum pathological cancer-free margin was 1 cm.
Postoperative recovery was satisfactory. The patient left hospital 1 weeks later. After 2 weeks of follow-up the patient did not exhibit any evidence of complication and could eat orally without any problem. Further treatment to the other metastatic lesion was refused and just follow up was done by hepatologist for more than 6 months.

Discussion

The prevalence of HCC is world widely increasing. It takes possession about one quarter of a million deaths yearly, representing the third largest cause of cancer-related death in the world [1]. Most of these cases develop in the setting of cirrhosis secondary to hepatitis B and C infections or alcohol consumption. HCC is related to profound prognosis due to its aggressive behavior and its coexistence with decompensated hepatic functions. At the progressive stage and in recurrent cases, HCC has a higher potential for extrahepatic metastasis [6]. The lung, abdominal lymph nodes and the skeleton are the common sites of extrahepatic metastasis. Among these, lung is the most common and earliest detectable area of extraheptatic metastasis. HCC metastasis is not usually found in the head and neck area. Owing to the advancement of HCC treatment modalities, patients can survive for longer periods of time, allowing more opportunities for metastasis to occur and grow significantly. The existing paper has already reported isolated cases of metastases to the head and neck area (Table 1) [1,2,6-9]. However, in endemic areas of hepatitis B such as Korea, the early detection program for HCC high-risk groups has made it rare for extrahepatic metastasis to be diagnosed before the primary tumor [10]. Lingual metastasis may be spreaded from systemic circulation, venous circulation or lymphatic circulation. Hematogenous spread appears to be the most common mechanism of distant metastasis [11]. Metastatic lesions can differ significantly in form. No recognized treatments for HCC metastases to the head-and-neck area have been established because such metastases are rare. In previous reports, the prescribed treatments have included surgery.
This case is the first one that HCC metastasizing to the dorsum of the tongue in the English literature as the clinical presentation of metastasis. Patients with an oral metastatic lesion accompanying with developed metastasis at other sites can be treated oral lesions surgically with palliative intent [12,13]. We also decide to do surgical excision of oral metastatic lesion to relieve symptom such as dysphagia and foul odor, his family members suffer from foul odor from the mass. In previous reports, six of seven patients were primarily found with only head-and-neck metastases (i.e., no other metastases), but two of them developed subsequent metastases within 1 year; data on the other patients are lacking [8,14,15]. The treatment of metastatic tumors requires careful deliberation, depending on the success or failure of treatment for the primary tumor, and on the existence of other sites of metastasis.
We introduce this first case of metastatic HCC in oral tongue. With the extended life expectancy of HCC patients, the incidence of rare metastasis is expected to increase in number for several years. The treatment guidelines for these conditions have not been well-studied and further studies to be needed.

Fig. 1.
A pinkish lobulated cancer located on the dorsal of the tongue.
kjorl-hns-2016-16159f1.tif
Fig. 2.
Head and neck CT shows (A) lobulated dorsal tongue mass with enhancement (arrow) and (B) known intracranial metastatic mass at Lt., occipital lobe (arrow).
kjorl-hns-2016-16159f2.tif
Fig. 3.
A microscopic finding shows large polygonal tumor cells with eosinophilic granular cytoplasms, round-to-oval nuclei, and prominent nucleoli. Many mitoses and deposits of yellow-green pigments are evident (H&E stain, ×400) (A). The tumor cells are positive for hepatocyte specific antigen (HSA stain, ×400) (B).
kjorl-hns-2016-16159f3.tif
Table 1.
Head and neck site of metastatic HCC in English literatures
Age/sex Site Size Another site metastasis Treatment Prognosis
55/M Gingiva 2×2 cm × Incisional biopsy Chemotherapy N/A
56/M Lacrimal gland 3.5×3 cm × Excisional biopsy TACE After 1 year, HCC recurrence
65/M Tongue base 2×2 cm × Excisional biopsy After 3 month, pulmonary metastasis
69/F Skull N/A × Excisional biopsy Radiation therapy TACE N/A
78/F Gingiva 2×2 cm Skull Lumbar vertebrae Excisional biopsy After 2 month, expired
70/M Mandible 3×2.5 cm × Excisional biopsy N/A

N/A: not analysis, HCC: hepatocellular carcinoma, TACE: transarterial chemoembolization

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