Relapsing polychondritis is a rare disorder, characterized by episodic inflammation and destruction of cartilagenous structure throughout the body. The most common presenting clinical manifestation is auricular chondritis;other types of presentation include inflammation of the cartilage of the nasal dorsum, with eventual collapse and saddle nose deformity. The majority of cases appear in patients of middle age with an approximately equal sex ratio. While the cause remains unknown, an autoimmune mechanism is thought to be the causative factor. Authors have recently experienced a case of relapsing polychondritis involving multiple organ systems, and causing auricular chondritis, hearing and vestibular dysfunction, saddle nose deformity and posterior scleritis in a 67 years old woman. So, we report this case with a revew of the literatures.