Surgical access to the midfacial structure for the removal of benign or malignant lesion traditionally has been through paranasal sinus, palate and external facial incisions. But, large lesions of the nose, paranasal sinuses and nasopharynx present a particularly difficult problem of surgical approach. The midfacial degloving approach has been developed by the association of sublabial and rhinoplasty incisions, with or without osteotomies of the nasal bone and frontal process of the maxilla. Thereby it furnishes unlimited exposure to the pyriform fossae and the lateral nasal walls, and its great advantages are no external scarring and the wide exposure of the total operative field. Recently the authors experienced a case of inverted papilloma involving the left nasal cavity, maxillary sinus, ethmoid sinus and anterior wall of sphenoid sinus and a case of palate mixed tumor involving the floor of nasal cavity, both maxillary sinuses and ethmoid sinuses which were removed successfully through midfacial degloving approach, so reported with some review of literatures.