In general, olfaction had seemed to be a relatively less significant sense than other senses(vision, hearing, taste, etc.), but it has been becoming a important sense associated with developing economics and cultures. Many morphological, fuctional studies on olfactory mucosa have been performed, but immunohistochemistry of olfactory mucosa has not been studied much so far. In our study, we used a lectin histochemistry on canine olfactory and respiratory mucosa and the results of distribution of glycoproteins are obtained as follows ; 1) In the ciliary laryer of olfactory epithelium, mannose, glucose and N-acetylglucosamine showed strong staining reactions. 2) In the olfactory epithilium(such as olfactory cells, sustentacular cells and basal cells), mannose and N-acetylglucosamine showed weak staining reactions. 3) In the Bowman's glands, N-acetylglucosamine showed a strong reaction and mannose, galactose and N-acetylgalactosamine showed weak reactions. 4) In the connective tissue of lamina propria, mannose and galactose showed weak reactions. 5) In the vascular endothelium, galactose showed a strong reaction and N-acetylglucosamine showed a weak reaction. The arterial endothelium showed the stronger reactions than vein's. Therefore, we need to do further immunohistochemical study on the olfactory mucosa for understanding of olfaction machanism and the roles of glycoprotein contents of olfactory epithelium.