Recently, there is a tendency to increase the number of epistatic patient, and in this treatment, many methods are employed, such as cauterization, anterior and posterior nasal packing and surgery. We selected 14 cases which has bled from the nasal septum, among the epistatic patients who visited to the E.N.T. opd. Of St. Paul's Hosp. from Oct, 1970 to Aug, 1971. In this cases we injected to the bleeding point with xylocaine and bosmine mixture which was commonly used in otolaryngology field. An injection of 1 to 3 c.c. of 1% xylocaine containing 1 : 1,000 bosmin was performed into the submucosa of the nasal septum in 14 cases of epistaxis. Nasal bleeding was controlled in 13 of 14 cases without nasal packing. We have been trying to treat the patients to let them have more comfortable sensation during the treatment and satisfactory results are made out.