A perforation was made at the anterior portions of the nasal septum, and auricular cartilage with perichondrium was grafted. The grafted tissue was taken and examined grossly and histologically 4 weeks later to evaluate the availability of the auricular cartilage autografting for the treatment of the nasal septal perforation. The results were as follows ; 1) Grossly, the transplanted site was covered with healthy nasal mucosa, scar formation was minimal, and no granulation tissue was observed. 2) Histologically, mucosa was regenerated completely at the transplanted site. The regenerated mucosa was ciliated columnar epithelium. 3) The grafted cartilage was intact without absorption or reperforation. Growth of the grafted cartilage and scattered ossification was observed, which suggested the regeneration potential of the perichondrium. 4) From the above results auricular cartilage autografting seemed to be one of the excellent surgical procedures for repair of the septal perforation.