As recent development of Immunology and Nuclear medicine, serum IgE and IgG values are helpful in diagnosis and evaluation of therapeutic effect of nasal allergy. The authors have observed changes of serum IgE and IgG levels before and after hyposensitization in the cases in order to assess how valuable these immunoglobulins are as direct evidence of therapeutic effect. Serum IgE and IgG level of 15 cases are checked at 6 month, 12 month, 18 month, and following results are obtained. After begining of hyposensitization, serum IgE level are decreased, serum IgG level are increased. The author thinks the follow up check must be performed for 3 years continusely.