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Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1987;30(1): 71-81. |
Influence of Various H1-antihistaminics on the Contractile Action of Norepinephrine in Mucosal Strip of Human Inferior Turbinate |
Gie Hwan Hong, MD, Ki Soo Oh, MD, Sang Sun Kil, MD, Bo Yung Moon, MD, Jang Yun Han, MD, and Yong Ju Yoon, MD |
Department of Otolaryngology, Chonbuk National University Medical Science, Korea |
인체 하비갑개 평활근에서 Norepinephrine의 근편 수축 작용에 미치는 제종 H1-항히스타민제의 영향 |
홍기환 · 오기수 · 길상선 · 문보영 · 한장연 · 윤용주 |
전북대학교 의과대학 이비인후과학교실 |
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ABSTRACT |
In this experiment, the influence of various H1-antihistamines on the contractile action of norepinephrine was studied in mucosal strip of human inferior turbinate. The results were as follows : 1) Histamine, norepinephrine and tyramine elicited the contractile response of mucosal strip of human inferior turbinate in dose dependent manner. 2) Contractile action of histamine was significantly inhibited by chlorpheniramine, methdilazine, chlorcyclizine or diphenhydramine, respectively. 3) Contractile response of mucosal strip of human inferior turbinate to norepinephrine was potentiated by chlorpheniramine and diphenhydramine but attenuated by chlorcyclizine and methdilazine. 4) Contractile response of mucosal strip of human inferior turbinate to tyramine was inhibited by chlorpheniramine, diphenhydramine, chlorcyclizine and methdilazine. From these result, it is suggested that some kinds of H1-antihistamines can modify the action of monoamines. More over it is inferred that the potentiation of contractile response of isolated mucosal strip of human inferior turbinate to norepinephrine by chlorpheniramine or diphenhydramine was due to inhibition of amine pump uptake mechanism at sympathetic nerve terminal.
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