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Korean Journal of Otorhinolaryngology-Head and Neck Surgery > Volume 31(2); 1988 > Article
Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1988;31(2): 194-201.
A Study of Normal Value of AP and SP in Guinea Pigs
MC Cha, MD, HN Kim, MD, YJ Shim, MA, JH Yoon, MD, and KH Chung, MD
Department of Otolaryngology, Yonsei University, College of Medicine, Korea
Guinea Pig의 정원창에서 측정한 Action Potential과 Summating Potential의 정상치에 관한 연구
차몽철 · 김희남 · 심윤주 · 윤주헌 · 정광현
연세대학교 의과대학 이비인후과학교실
ABSTRACT

The electrocochleography which is measurable to cochlear potentials is a useful method for detection of hearing threshold, for the differential diagnosis of sensorineural hearing loss and for the study of auditory physiology. We have measured the normal value of SP, SP/AP at the round window in 20 healthy guinea pigs as a preliminary study for the differential diagnosis of sensorineural hearing loss. The results were as follows : 1) AN1 threshold : AN1 threshold was significantly decreased as the frequency of stimuli was increased : AN1 thresholds were 53.93±12.41 dB SPL at 0.5 kHz, 46.52±14.30 dB SPL at 1 KHz, 36.30±8.01 dB SPL at 2 kHz, 22.17±13.26 dB SPL at 4 kHz, 17.73±7.30 dB SPL at 8 kHz. 2) Amplitude and latency of AP according to the intensity of stimuli : As the intensities and frequencies of stimuli were increased, the amplitude of AP was significantly increased. The reverse relationship was observed between amplitude and latency of AP. As the frequency of stimuli was increased, the amplitude-latency curve became steeper. 3) SP, AP, SP/AP according to the parameters of stimuli. (1) ISI : The plateau of AP was noted at ISI between 80 msec and 320 msec. (2) The intensity and frequency of stimuli : The SP, SP/AP ratio were significantly increased as the intensity and frequency of stimuli were increased.

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