| The Change of Lymphocyte Subpopulations by TNM Classification in Head and Neck Cancers |
| Sang Yoon Kim, MD1, Seong Won Yoon, MD1, Seung Joo Yoo, MD1, Kwang Chol Chu, MD1, Young Joo Cho, MD2, and Mi Gyoung Choi, MS2 |
| 1;Department of Otolaryngology, College of Medicine, University of Ulsan, Seoul, 2;Asan Institute for Life Science, Seoul, Korea |
| 두경부 악성종양 환자에서 TNM 분류에 따른 말초혈액 림프구 아집단의 변화 |
| 김상윤1 · 윤성원1 · 유승주1 · 추광철1 · 조영주2 · 최미경2 |
| 울산대학교 의과대학 이비인후과학교실1;아산생명과학 연구소2; |
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| ABSTRACT |
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T cell function and natural killer(NK) cell activity are altered in many patients of head and neck cancers. However, the correlation between these immunological alterations and tumor progression has not been elucidated yet. This study was designed to assess the effect of tumor progression on the immunological variables, such as T lymphocytes and NK cell populations, and T4/T8 ratio. We measured peripheral blood lymphocytes subpopulations in 60 patients with primary head and neck cancers, using monoclonal antibodies(CD3, CD4, CD8, CD16, and CD56), and analyzed these data by AJCC TNM classification system(1998). In conclusions, T lymphocyte populations were decreased, NK cell populations were increased, and T4/T8 ratio was not affected in patients with head and neck cancers. These changes might be affected by TNM stage, and cervical metastasis might be the most important factor to affect lymphocyte subpopulations.
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| Keywords:
Head and Neck CancerㆍLymphocyteㆍT LymphocyteㆍT4/T8 RatioㆍNatural Killer Cell. |
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