Sjören's syndrome is a chronic autoimmune disease which consists of the triad of keratoconjuntivitis sicca, xerostomia and rheumatoid arthritis or other connective tissue disease, and two of the three components are generally considered sufficient for the diagnosis. Recently the authors experienced a case of Sjögren's syndrome with bilateral parotid gland enlargement in a 54-year-old female, and we report this case.