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Korean Journal of Otorhinolaryngology-Head and Neck Surgery > Volume 37(6); 1994 > Article
Korean Journal of Otorhinolaryngology-Head and Neck Surgery 1994;37(6): 1142-7.
Expression of 72 kD Heat Shock Protein with Noise Induced Temporary Threshold Shift in Rat Cochlea
Hyun Ho Lim, MD1, and Richard A. Altschuler2
1;Department of Otolaryngology-Head and Neck Surgery, Korea University, College of Medicine, Seoul, Korea, 2;College of Medicine and Kresge Hearing Research Institute, University of Michigan, U.S.A.
백서의 와우에서 소음자극에 의한 72 kD Heat Shock Protein의 발현과 일시적 청각역치 상승과의 관계에 관한 연구
임현호1 · Richard A. Altschuler2
고려대학교 의과대학 이비인후-두경부외과학교실1;미시간대학교, KRESGE HEARING RESEARCH INSTITUTE2;
ABSTRACT

Heat shock proteins(HSPs) are induced in cells by temperature elevation or other stressful treatment and these proteins likely play a role in cellular repair and survival mechanisms. In the peripheral auditory system several investigators have demonstrated the induction of 72 kD HSP with hyperthermia and transient ischemia and we have previously shown the noise induced HSP 72 expression in outer hair cells of the rat cochlea. Animals were exposed to 110 dB SPL broad band noise for 1.5 hours. This exposure resulted in 30-50 dB threshold shift for 3-4 hours. Animals sacrificed 6 hours after stimulation showed noise induced HSP 72 immunoreactive staining of outer hair cells and stria vascularis with no staining of inner hair cells or spiral ganglion cells. Animals exmined for scar formation using histochemical and immunocytochemical methods for actin and cytokeratin staining showed no noise induced pathology even 24 hours after exposure. HSP 72 is therefore expressed under conditions of temporary threshold shift and may be involved in protection from insults. 

Keywords: HSP 72ImmunohistochemistryTTSOuter hair cellsCochleaRat.
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