Toxic shock syndrome(TSS) is an acute disease involving multiple organs. Four major criteria, which are involvement of multiple organ systems, fever, hypotension or shock, and rash with subsequent desquamation should be fulfilled for the diagnosis. The exact pathogenesis is not well understood, however it is thought to be due to effects of an enterotoxin produced by certain strains of staphylococcus aureus. We described here 3 cases of TSS associated with intranasal packings. Symptoms such as high fever, nausea, vomiting, sore throat and skin rash abruptly developed on the postoperative second or third day. Staphylococcus aureus was identified in the nasal discharge.