The use of synthesis has become a popular method for ossicular reconstruction. Although its extrusion rate was much improved, displacement of the ossicular framework has been a problem in ossiculoplasty. Therefore, correct fixation of ossicular prosthesis with neibouring structures is needed. Experimental laser welding of human ossicles and various synthetic materials such as Polyecel, Silicon, Bioglass ceramic, Aluminium oxide ceramic, Ionos and Silastic was performed using CO₂, Nd-YAG and Argon laser. Pigmented ultra molecular weight polyethylene was melted by laser beam an covered the surface of ossicle. Other materials were destroyed or vaporized laser beam. Scanning electron microscopic view of melted polyethylene showed disappearance of irregularity on the surface of prosthesis.