| A Case of Proliferative Verrucous Leukoplakia With Insidious Transformation Into Oral Verrucous Carcinoma |
Hyeong Jin Kim
, Hye Ran Lee
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| Department of Otorhinolaryngology-Head and Neck Surgery, International St. Mary’s Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea |
| 잠행적으로 구강 우상암으로 진행한 증식성 우상형 백반증 1예 |
| 김형진
, 이혜란
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| 가톨릭관동대학교 의과대학 국제성모병원 이비인후-두경부외과학교실 |
| Correspondence |
Hye Ran Lee ,Tel: +82-32-290-3051, Fax: +82-32-290-3879, Email: ln012673@gmail.com
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Received: 13 February 2026; Revised: April 6, 2026 Accepted: 13 April 2026. Published online: 24 June 2026. |
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| ABSTRACT |
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Proliferative verrucous leukoplakia (PVL) is a rare and aggressive subtype of oral leukoplakia characterized by multifocal progression, frequent recurrence, and a high risk of malignant transformation. Diagnosis is often delayed due to non-linear clinical course and evolving histopathologic features. We report a case of PVL-associated verrucous carcinoma in a 68-year-old non-smoking woman. The lesion initially presented as a localized elevated plaque on the left buccal mucosa and was diagnosed as squamous papilloma. Over a 6-year period, it progressively expanded with prominent verrucous changes, and repeated biopsies showed variable histologic findings. Wide transoral excision was performed, and the final pathology revealed verrucous carcinoma with a pushing growth pattern without cytologic pleomorphism or infiltrative invasion, which is consistent with the malignant transformation of long-standing PVL. This case highlights the diagnostic challenges of PVL and underscores the importance of prioritizing clinical suspicion over isolated histologic findings. |
| Keywords:
Histologic transformationㆍ Oral leukoplakiaㆍ Proliferative verrucous leukoplakiaㆍ Verrucous carcinoma |
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