| Advanced Neuroendocrine Carcinoma of the Pharyngolaryngeal Region With Distant Metastasis: A Report of Two Cases |
Dorjsuren Tsagaankhuu1
, Jeonghwan Kim1,2
, Jung-Woo Choi3
, Soon Young Kwon1
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1Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea
2Department of Biomedical Informatics, Korea University College of Medicine, Seoul, Korea
3Department of Pathology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea |
| 원격전이를 동반한 인후두 영역의 진행성 신경내분비암종 2예 |
| Dorjsuren Tsagaankhuu1
, 김정환1,2
, 최정우3
, 권순영1
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1고려대학교 의과대학 안산병원 이비인후-두경부외과학교실
2고려대학교 의과대학 의료정보학교실
3고려대학교 의과대학 안산병원 병리학교실 |
| Correspondence |
Soon Young Kwon ,Tel: +82-31-412-4920, Fax: +82-31-412-5174, Email: entkwon@korea.ac.kr
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Received: 9 March 2026; Revised: May 6, 2026 Accepted: 6 May 2026. Published online: 24 June 2026.
*Dorjsuren Tsagaankhuu and Jeonghwan Kim contributed equally to this work. |
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| ABSTRACT |
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Neuroendocrine carcinoma (NEC) of the head and neck is a rare and aggressive malignancy accounting for less than 1% of head and neck cancers. Its nonspecific presentation mimics squamous cell carcinoma, and immunohistochemistry is essential for diagnosis. We report two cases of NEC arising in the pharyngolaryngeal region. The first patient, a 50-year-old male, presented with oropharyngeal NEC with mixed small and large cell features and synchronous hepatic and pulmonary metastases; he was treated with palliative chemotherapy. The second, a 64-year-old male, had small cell NEC of the left aryepiglottic fold with a pulmonary nodule; he underwent CO2 laser-assisted supraglottic partial laryngectomy and pulmonary wedge resection, followed by chemotherapy and radiotherapy. Both cases were confirmed by synaptophysin and CD56 positivity. These cases underscore the need for accurate immunohistochemical diagnosis, comprehensive staging, and multidisciplinary treatment. |
| Keywords:
Immunohistochemistryㆍ Ki-67 antigenㆍ Neuroendocrine carcinomaㆍ Pharyngeal neoplasmsㆍ Synaptophysin |
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