| Clinical Characteristics and Risk Factors for Major Complications in Recurrent Respiratory Papillomatosis: A Single-Institution Retrospective Study |
Dae Hyun Kim
, Jae-Yol Lim
, Young Min Park
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| Department of Otorhinolaryngology-Head and Neck Surgery, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Korea |
| 단일 기관 후향적 연구를 통해 본 재발성 호흡기 유두종증 주요 합병증의 임상적 특징 및 위험 인자 |
| 김대현
, 임재열
, 박영민
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| 연세대학교 의과대학 강남세브란스병원 이비인후과학교실 |
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Received: 19 May 2026; Revised: September 1, 2026 Accepted: 3 September 2026. Published online: 16 October 2026. |
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| ABSTRACT |
Background and Objectives
Recurrent respiratory papillomatosis (RRP) is a rare HPVassociated disease characterized by recurrent papillomatous lesions within the airway.
Subjects and Method
We retrospectively analyzed 165 patients who were treated for RRP at a single tertiary institution between 2005 and 2021 and evaluated clinical characteristics, treatment outcomes, and risk factors for major complications.
Results
Juvenile-onset RRP (JO-RRP) accounted for 11.5% of the cases, demonstrating a significantly more aggressive clinical course than adult-onset RRP (AO-RRP). JO-RRP patients showed markedly higher rates of subglottic spread, tracheotomy, and laryngeal stenosis, while no cases achieved remission. CO2, PDL, and KTP lasers were used for surgical treatment, often combined with intralesional cidofovir injection and HPV vaccination. Our findings suggest that JO-RRP is associated with poor prognosis and aggressive airway involvement. Tracheotomy and repeated surgeries are highly likely to serve as indicators reflecting disease severity, a prolonged disease course, lower respiratory tract involvement, and airway obstruction.
Conclusion
These findings suggest that continuous surveillance for complications is essential in patients with a high disease burden. |
| Keywords:
Adult onsetㆍ Human papilloma virusㆍ Juvenile onsetㆍ Papillomatosis |
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