Recently, tumors became to have more and more interest in both for basic researchers and clinicians, because most inflammatory diseases which had threatened our livelihood in the past are under control with antibiotics. Clinically, the neoplastic lesions of the oto-rhino-laryngological field are detected early for their earlier symptoms and external visibility. Moreover, the anatomical and histological characteristics of upper respiratory tract such as the thin wall of the paranasal sinuses with side continuity and intimate contact of mucosa or skin to underlying cartilage on anterior nasal septum, nasal alae, epiglottis and larynx give the adequate condition to spread the neoplastic lesions early, easily rapidly and widely and oto-rhino-laryngeal tumors to have peculiar behaviors. With the development of irradiation therapy and chemotherapy including surgical technic, there have been great advance of anticancer therapy and we are highly expecting to solve this problem like for anti-inflammatory in a near future. To solve this problem, it is required to have sound knowledge about clinical and histopathological characters of the tumors as much as the knowledge of therapeutic measures. Although a lot of reports have been made public about the tumors of oto-rhino-laryngological field in Korea and foreign countries, still there have left something to be desired about the general realities and acutal conditions, and most of these were confined to only one organ or the period handled the cases was short. So the auther studied the clinical and histopathological analysis of tumors of oto-rhino-laryngological field which were confirmed by biopsy during last twelve and a half year in Severance hospital. The following results were obtained. 1) Among 1,758 cases of biopsy, tumors : 1,060 (60.3%), inflammations : 639(36.3%), and others : 59(3.4%). In tumors, benign tumors :526(47.7%) and malignant tumors :534(52.3%). 2) The mean age for benign tumors was 38.1 and for malignant tumors, 52.4. Which showed somewhat earlier tendency to tumor age than foreigners. 3) The male to female ratio was 2.2 : 1 for benign tumors and 3.2 : 1 for malignant tumors showing male preponderance in both. 4) In the clinical data, hoarseness was the most frequent chief complaint for laryngeal tumors, nasal obstruction for nasal and paranasal tumors, palpable cervical mass and nasal obstruction for pharyngeal tumors, and oral and cervical mass for oral tumors. 5) The duration of illness was less than one year in 60.2% of benign tumors and 83.8% of malignant tumors. 6) The most common histopathological type of benign non-neoplastic tumors was polyp with the incidence of 89.3%. 7) The most common histopathological type of benign neoplastic tumors was papilloma with the incidence of 53.2% and then in order of frequency was angiofibroma, hemangioma, and mixed tumor etc. 8) The most common histopathological type of malignant tumors was squamous cell carcinoma with the incidence of 69.8%(363/534) and then in order of frequency was malignant lymphoma, anaplastic carcinoma, basal cell carcinoma etc. 9) The clinical and histopathological analysis for aural lesions was inavailable because of the data size.